Some Volunteers have a High Fever! AstraZeneca has just Suspended Trials, and Pfizer’s New Coronavirus Vaccine has Exposed Side Effects

According to Pfizer, the side effects of volunteers participating in clinical trials include fatigue, headache, chills, muscle pain, etc. Some volunteers also have fever symptoms, and some volunteers have high fever.

Recently, the clinical trials of the new coronavirus vaccine of two international pharmaceutical giants have consecutive side effects.

On September 8, local time, AstraZeneca, a pharmaceutical company headquartered in the United Kingdom, announced that it had suspended the third phase of clinical trials of the new coronavirus vaccine due to an unexplained disease in one of the volunteers. On the 15th, Pfizer Pharmaceuticals Co., Ltd. of the United States stated on the 15th that in the phase 3 clinical trial of the new coronavirus vaccine developed by the company and the German biotech company, some volunteers had mild to moderate side effects.

AstraZeneca Suspends Trial of New Coronavirus Vaccine

AstraZeneca's new coronavirus vaccine is the first vaccine to enter the third phase of clinical trials. According to the research released by The Lancet in July, in the first and second phases of the vaccine, 60% of the volunteers had side effects, including fever, headache, muscle pain and reactions at the injection site. These side effects described as 'mild or moderate' and resolved during the trial.

AstraZeneca said in a statement on September 8, 'We have initiated standard review procedures and reviewed safety data, and suspend vaccine trials. This is a routine behavior. During the investigation, once there is an unknown test in a certain trial, Because of the underlying disease, this behavior must be taken to ensure the integrity of the trial.'

Prior to this, many countries have ordered the company's vaccine in advance. The British government announced in June that it would purchase 100 million doses of AstraZeneca vaccine. Germany, France, Italy and the Netherlands formed the 'Vaccine Alliance' in June and signed an agreement with AstraZeneca to book 400 million doses of vaccine. The United States invested US$1.2 billion in a vaccine developed by Oxford University and AstraZeneca in May and ordered 300 million doses.

According to Reuters, the European Commission said on August 27 that it had signed a contract with AstraZeneca on behalf of E.U. countries to purchase at least 30 million doses of its new coronary pneumonia vaccine candidate. Prior to this, the European Union had signed a pre-purchase agreement with AstraZeneca at the beginning of the month, which added the option of purchasing an additional 100 million doses of vaccines, which will be distributed among the 27 E.U. countries in proportion to the population.

In addition, Australian Prime Minister Morrison announced on August 19 that the Australian government has signed a letter of intent with the British AstraZeneca Pharmaceutical Company. Once the new coronavirus vaccine developed by the company and Oxford University is proved to be safe and effective, Australia will produce the vaccine in its own country.

Vaccine Volunteers of Pfizer have Side Effects

On September 17th, Pfizer Pharmaceuticals Co., Ltd. of the United States stated on the 15th that in the phase 3 clinical trial of the new coronavirus vaccine developed by the company and the German biotech company, some volunteers who participated in the trial had mild to moderate side effects. reaction.

According to Pfizer, the side effects of volunteers participating in clinical trials include fatigue, headache, chills, muscle pain, etc. Some volunteers also have fever symptoms, and some volunteers have high fever.

Because the data comes from a double-blind trial, currently Pfizer cannot distinguish between volunteers who have used a vaccine or a placebo. Catherine Johnson, the company's head of vaccine research and development, said that the independent data monitoring committee can obtain unblinded data and will notify the company if they think there is a security risk, but they have not done so so far.

According to reports, the vaccine’s Phase 3 clinical trial was originally planned to recruit 30,000 volunteers. Currently, more than 29,000 people have been recruited, and more than 12,000 volunteers have received the second dose of the vaccine. Recently, Pfizer and the German Biotech Company announced that they will expand the scale and diversity of volunteer participation, adding a group of young people with a minimum age of 16, as well as people living with HIV and hepatitis virus. A total of 44,000 people are planned to be recruited. Participate in Phase 3 clinical trials of the vaccine. The report on the vaccine effectiveness conclusion is expected to be announced at the end of October.